Speaker: Dr. Richard Roy (McGill University)
Where: L-GE 110 | When: 1:15 pm “Germ Line Stem Cell Integrity and Quiescence: AMPK Links Epigenetic Change to Physiological States” Abstract: Germ cells represent the totipotent stem cell lineage in most organisms and are precious since they are essential to propagate genes into future generations. Not surprisingly various mechanisms have evolved to protect this lineage during lean times, presumably to ensure that mutations are not incurred due to a lack of appropriate building blocks during growth and cell division. In C. elegans the AMP activated protein kinase (AMPK) is one of these mechanisms through its ability to phosphorylate key targets, ensuring that cell divisions are attenuated during periods of duress. Our findings suggest that AMPK also mediates the modification of the chromatin through novel regulatory pathways that ensure appropriate germ cell integrity and reproductive fitness following periods of energy stress. Photos By: Michael Chung Comments are closed.
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