Speaker: Dr. Rodrigo Reyes Lamonthe (McGill University)
Where: L-GE 110 | When: 1:15 pm “Using fluorescence microscopy to understand biochemistry in live cells” Abstract: Our understanding on the biochemical processes in cells is limited by the impossibility to replicate the intracellular conditions in test tubes. Our work in the lab aims to bypass this limitation by generating and using live cell imaging tools to study biochemistry. In my talk, I will discuss recent work using Escherichia coli where we studied the multi-component machine that coordinates DNA replication, the replisome. I will show that, in contrast to what was previously believed, most replisome subunits have a high turnover during active synthesis, including the DNA polymerase. This suggests that the synthesis of DNA in both strands occurs discontinuously. I will then speculate on the potential function of this mode of action. Photo By: Michael Chung Comments are closed.
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